Method for the determination of the confluence of a cell...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S395000, C435S401000, C435S004000

Reexamination Certificate

active

06946290

ABSTRACT:
The invention relates to a novel method, permitting the semiquantitative determination of the confluence of a cell layer on the total surface of a porous biomaterial, without irreversible damage to part or indeed all of the hybrid construct. A method is described for the first time, which is able to detect the formation of the confluence or the confluence itself, without destroying the hybrid construct, and thus permits the finished hybrid product to be withdrawn from the essential growth conditions only after the determination of the completed confluence, and to immediately direct it to its further use.

REFERENCES:
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patent: WO 97 49799 (1997-12-01), None
1994, Rapid Visualization of Viable and Nonviable Endothelium on Cardiovascular Prosthetic Surfaces by Means of Fluorescent Dyes C. Gillis, A Haegerstrand et al., J. Thorac. Cardiovascular Surgeon, 108, 1043-1048.
1991, 111-Indium is an Unreliable In Vivo Label for Vascular Endothelial Cells, M.B. Herring et al., Ann Vasc. Surg. 5, 424-428.
1984, Manual of Histological Techniques, Churchill Livingstone, Edinburgh J. D. Bancroft et al.
1994, A New, Automated and Accurate in Vitro Method to Quantify Endothelial Cells Attached to Vascular Prostheses, M.J.T. Visser et al., Thrombosis and Haemostasis, 72 (1), 146-150.

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