Method for the determination of plasminogen activators (PA)

Details Method for the determination of plasminogen activators (PA) Method for the determination of plasminogen activators (PA)

1986-04-09

1989-04-04

Rosen, Sam

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving blood clotting factor

435 4, 436 69, C12Q 156, G01N 3386

Patent

active

048186902

ABSTRACT:
A method for the determination of urokinase (UK) or tissue plasminogen activator (t-PA) is described, in which the activator is incubated with plasminogen, with a polysulfuric ester of a saccharide or with a sulfated sugar and, where appropriate, fibrin or fibrin degradation products, and the conversion of plasminogen into plasmin is determined, and agents suitable for this method are described.

REFERENCES:
patent: 4011142 (1977-03-01), Jacobi
patent: 4033824 (1977-07-01), Karges et al.
patent: 4605614 (1986-08-01), Nagasawa et al.
Markwardt et al.--Chem. Abst., vol. 89 (1978), p. 36482k.
Ranby, "Studies on the Kinetics of Plasminogen Activation by Tissue Plasminogen Activator," Biochimica et Biophysica Acta, 704:461-469 (1982).
Patricia Andrade-Gordon and Sidney Strickland, Biochemistry 25:4033-4040, 1986.
E.-P. Paques, H.-A. Stohr, N. Heimburger, Thrombosis Research 42:797-807, 1986.

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