Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1995-03-29
1997-03-11
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
435 6, 435 71, 435 721, 435 74, 436 69, 436501, 436506, 436548, C12Q 156
Patent
active
056100248
ABSTRACT:
In order to determine lupus anticoagulant (LA) antibodies in blood, plasma or tissue samples by means of the inhibitory effect of these antibodies on the neutralizing effect of protein C on the blood coagulation system, a defined amount of activated protein C is added to the sample, after incubation the remaining amount of a physiological substrate of protein C or protein S activity in the sample is determined according to known methods and the amount of LA antibodies present is calculated by comparison with a standard containing no LA antibodies. The method according to the present invention can be used to diagnose a predisposition to thrombotic events or disease-dependent risk of thrombosis as well as to monitor a therapy.
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Muller-Berghaus Gert
Potzsch Bernd
Seelig Christoph
Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.v.
Spiegel Carol A.
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