Method for the determination of an ion with increased sensitivit

Details Method for the determination of an ion with increased sensitivit Method for the determination of an ion with increased sensitivit

1991-05-10

1993-06-01

Rollins, John W.

Chemistry: analytical and immunological testing

Blood gas

436 74, 436164, 514608, 514614, 514639, 514731, 514732, 564250, 564251, 568716, 568719, G01N 3350, G01N 3320, G01N 2100, A61K 316

Patent

active

052159248

ABSTRACT:
The invention relates to a method for determining an ion in an aqueous sample. The method involves contacting the sample with a water immiscible material including an ionophore, a pH indicator and a compound which stabilizes sensitivity of the assay. The ion reacts with the ionophore in the water immiscible material, releasing a proton which reacts with the pH indicator generating a color change which is representative of the ion to be measured. The stabilizing compound stabilizes this change. Also described are compositions including the three recited elements, and various new compounds useful as the stabilizer.

REFERENCES:
patent: 3800051 (1974-03-01), Barnhart et al.
patent: 4990633 (1991-02-01), Negele et al.
G. Brown, et al., Chem. Abst. 87: 193625k, 1977.
P. Juvvik, et al., Chem. Abst. 79: 15265b, 1973.
Brown, G., et al. Eur. J. Med. Chem.-Chim. Therap. 12:361-363 (1977).
Juvvik, e al. J. Chrom. 84:414-416 (1973).

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