Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-12-18
1999-08-24
Arthur, Lisa B.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 4353201, 536 232, 536 2431, 536 2433, C12Q 168, C12P 1934, C12N 1563, C07H 2104
Patent
active
059423935
ABSTRACT:
A method for the detecting whether methyladenosine phosphatase (MTAse) is present in a cell sample in either a catalytically active or catalytically inactive form. In one respect, the method comprises adding oligonucleotide probes to the sample, which probes are capable of specifically hybridizing to any MTAse encoding nucleic acid in the sample under conditions favoring that hybridization. Absence of MTAse in a sample is considered to be indicative of malignancy. Polynucleotides encoding MTAse, MTAse peptides and antibodies to MTAse, as well as kits for performing the methods of the invention, are provided.
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Carson Dennis A.
Nobori Tsutomu
Takabayashi Kenji
Arthur Lisa B.
The Regents of the University of California
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