Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-08-07
2007-08-07
Horlick, Kenneth R. (Department: 1637)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C536S022100, C536S024300, C536S025300
Reexamination Certificate
active
10339604
ABSTRACT:
Method for the detection of the antibiotic resistance spectrum ofMycobacteriumspecies present in a sample, possibly coupled to the identification of theMicobacteriumspecies involved, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the antibiotic resistance genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least one of the rpoB gene probes, as specified in table 2, under the appropriate hybridization and wash conditions; (iv) detecting the hybrids formed in step (iii); (v) inferring theMycobacteriumantibiotic resistance spectrum, and possibly theMycobacteriumspecies involved from the differential hybridization signal(s) obtained in step (iv).
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De Beenhouwer Hans
Jannes Geert
Machtelinckx Lieve
Portaels Françoise
Rossau Rudi
Horlick Kenneth R.
Innogenetics N.V.
Sterne Kessler Goldstein & Fox PLLC
Tung Joyce
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