Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-10-23
1995-05-30
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 435 793, 436518, 436531, 436813, 436815, G01N 33574
Patent
active
054200121
ABSTRACT:
The invention relates to diagnosis of reactive conditions, such as malignant tumors. According to the invention, the amount of cellular fibronectin in a body fluid is determined, and an elevated amount is used as a marker for a reactive condition. The method is especially suitable for the diagnosis of carcinomas, such as colon carcinoma.
REFERENCES:
patent: 4980279 (1990-12-01), Peters et al.
Laitinen et al., "Distribution of Extra-Domain (ED)-Containing Form of Cellular Fibronectin in Human Solid Tumors", Int. Congr. Acad. Pathology, Dublin 1988, Abstract. 144.
Vartio et al., "Differential Expression of the ED Sequence-Containing Form of Cellular Fibronectin in Embryonic and Adult Human Tissues", J. Of Cell Science, vol. 88, pp. 419-439 (1987).
Ylatupa et al., Journal of Immunological Methods, 163 (1993) 41-47; 1993 Elsevier Science Publishers B.V. "Competitive Enzyme Immunoassay for Quantification of the Cellular Form of Fibronectin (EDAcFN) In Blood Samples" pp. 41-47.
Walle et al., Scand J. Immunol. 31, 535-540, 1990, "Cellular Fibronectin in Rheumatoid Synovium and Synovial Fluid: a Possible Factor Contributing to Lymphocytic Infiltration".
Linnala et al., Federation Of European Biochemical Societies, Feb., 1992, vol. 317, No. 1,2, pp. 74-78, "Human Amnion Epithelial Cells Assemble Tenascins and Three Fibronectin Isoforms in the Extracellular Matrix".
Preprint: "Cellular Fibronectin (EDAcFN) Concentration in Various Body Fluids", by Ylatupa et al.
Preprint: "Cellular Fibronectin in Serum and Plasma. A Potential New Tumor Marker?", by Ylatupa et al.
Paasivuo Raili
Partanen Paul
Virtanen Ismo
Ylatupa Sari
Kepplinger Esther M.
Locus Genex Oy
Wolski Susan C.
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