Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Patent
1991-08-16
1993-03-30
Rosen, Sam
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
436 65, 436 87, 436503, 436504, 436510, G01N 3368
Patent
active
051983664
ABSTRACT:
The present invention relates to a method for an early stage detection of three specific pregnancy-related disorders: preeclampsia, intrauterine growth retardation and preterm delivery. According to the method, an antigen consisting of a specific human-derived placental soluble protein, known as PP-13, is determined by radioimmunoassay or ELISA. In the radioimmunoassay method, the PP-13 is labelled by a radioactive iodine and the bounded iodine is counted and correlated with standard curves. The best results are obtained when the protein to be labelled by radioactive iodine is present at a concentration of above 0.71 mg/ml. In case of the ELISA method, the quantitative determination of PP-13 is carried out with an alkaline phosphatase substrate and measured at an optical density of 405 nm.
REFERENCES:
patent: 4500451 (1985-02-01), Bohn et al.
Rosen Sam
Silberman Michael
Technion Research & Development Foundation Ltd.
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