Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-03-16
1995-03-21
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435 792, 436 63, 436 64, 436813, G01N 33574, G01N 3353, G01N 33543
Patent
active
053994825
ABSTRACT:
The present invention concerns a method for the detection of micrometastases of ectodermal or entodermal tumors. Cells from mesenchymal tissue, preferably from bone marrow, are subjected to a fractional lysis. Cytokeratins or fragments thereof are immunologically detected in the cell supernatant.
REFERENCES:
patent: 4294284 (1981-10-01), Jones et al.
patent: 5168044 (1992-12-01), Joyce et al.
Abstract of SU 1 649 444, Derwent Publications Ltd. Database WPI, Section Ch, Week 9217.
Bergmeyer, Methods of Enzymatic Analysis, 3rd Edition, vol. II, 1983, p. 33, table 2.
Schlimok et al., "Micrometastatic Tumor Cells in Bone Marrow of Patients with Gastric Cancer: Methodological Aspects of Detection and Prognostic Significance," Eur J Cancer 27(11) 1461-65 1991.
Hall et al., "Characterization of the Intermediate Filament Proteins of Murine Mammary Gland Epithelial Cells," Experimental Cell Research, 162; pp. 379-389, 1986.
Bodenmueller Heinz
Riethmueller Gert
Boehringer Mannheim GmbH
Scheiner Toni R.
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