Method for the detection of diseases associated with the metabol

Details Method for the detection of diseases associated with the metabol Method for the detection of diseases associated with the metabol

1988-10-20

1990-05-22

Nucker, Christine M.

Chemistry: analytical and immunological testing

Cancer

435 25, 436 93, 436813, G01N 33493, G01N 3350

Patent

active

049277677

ABSTRACT:
A method is provided for the detection of a disease associated with the metabolic abnormality of L-fucose in a subject. The concentration of free L-fucose in a specimen from the subject is determined and the determined concentration is compared with a normal concentration of free L-fucose.

REFERENCES:
patent: 4338811 (1982-07-01), Miyagi et al.
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Petrini, M.; Azzara, A.; Polidori, R.; Vatteroni, M. L.; Caracciolo, F.; "Serum Factors Inhibiting Some Leukocytic Functions in Hodgkin's Disease" Clinical Immunology and Immunopathology, vol. 23, pp. 124-132, (1982).
Willems P. J.; Darby J. K.; DiCioccio, R. A.; Nakashima, P.; Eng., C; Kretz, K. A.; Cavilli-Sfolza, L. L.; Shooter, E. M., O'Brien J. S., "Identification of a Mutation in the Structural .alpha.-L-Fucosidase Gene in Fucosidosis," Am J. Hum. Genet; 43:756-763, 1988.
Maler, T.; Duthie, M.; Alon, N.,; Riordan J. R.; ".alpha.-L-Fucosidase is Quantitatively Reduced in Cultured Lymphoblasts from Patients with Cystic Fibrosis", J. of Biol. Chem., vol. 256, No. 3, 2/10/81, pp. 1420-1427.
Waalkes, T. P.; Mrochek J. E.; Dinsmore, S. R.; Tormey, D. C., "Serum Protein-Bound Carbohydrates for Following the Course of Disease in Patients with Metastatic Caicinoma," Natl. Cancer, Inst., vol. 61, No. 3, Sep. 1978, pp. 703-707.

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