Method for the detection of creatinine

Details Method for the detection of creatinine Method for the detection of creatinine

1998-09-28

1999-12-14

Wallenhorst, Maureen M.

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-n

436106, 436164, 436169, 436904, 422 55, 422 56, G01N 3370

Patent

active

060016566

ABSTRACT:
Disclosed is an improvement to the assay for creatinine in fluid test samples by contacting the test sample with a reagent formulation containing cupric ions, a hydroperoxide and an oxidizable dye. The improvement involves the inclusion of one or more selected quinolines in the reagent formulation. When the quinoline is substituted with methyl in the 2-5 position and/or a methoxy in the 2-6 position auto-oxidation of the oxidizable dye is reduced. When the quinoline is further substituted in an otherwise unsubstituted carbon atom in the 2-8 position, the assay's resistance to interference from hemoglobin and ascorbate is increased.

REFERENCES:
patent: 5173431 (1992-12-01), Pugia et al.
patent: 5362633 (1994-11-01), Pugia
patent: 5374561 (1994-12-01), Pugia
patent: 5610073 (1997-03-01), Chu et al.
patent: 5662867 (1997-09-01), Pugia et al.
patent: 5733787 (1998-03-01), Messenger et al.
Traylor et al, Tetrahedron, vol. 40, No. 3, pp. 553-568, 1984.

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