Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1994-06-03
1996-09-17
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435 72, 435 722, 435 731, 435 732, 435 733, 435 734, 435 735, 435961, 435962, 435974, 436509, C12Q 100
Patent
active
055567452
ABSTRACT:
The invention is a simple and rapid method for immune complex dissociation and destruction of rheumatoid factors. It permits the quantitative measurement of the total, i.e., free and immune complex-bound, antigen contained in a test sample. The method involves heating the test sample to a point sufficiently above 65.degree. C. at which the antigen-binding function of antibodies is destroyed. As a consequence, interference by rheumatoid factors is eliminated and the antigen is released from immune complexes, after which it can be measured in an antigen assay that recognizes the heat-denatured antigen.
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Boni Jurg
Schupbach Jorg
Nucker Christine M.
Stucker Jeffrey
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