Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
1999-08-03
2001-11-06
Hartley, Michael G. (Department: 1619)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001410, C424S009340, C424S009341
Reexamination Certificate
active
06312661
ABSTRACT:
The invention relates to a method of detecting and localizing malignant tumours in the body of a human being. The invention further relates to the therapeutic treatment of these tumours in the body of said being. The invention also relates to a pharmaceutical composition to be used in these methods.
Neurotensin (NT) is a neuropeptide that exerts numerous effects in the gastrointestinal tract and in the brain and is already known since a number of years. NT has been studied by several groups, mainly on its normal function in warm-blooded animals and humans. Further it is known in the art that neurotensin receptors are present in several tumour cells, like human colon carcinoma and human meningomas located in or around tissues (colon, brain) which in healthy conditions contain neurotensin receptors (see e.g. WO 95/22341).
Recently radiolabelled octreotide, a cyclic peptide containing 8 amino acid moieties, is commercialized under the brand name OctreoScan® 111. This diagnosticum, labelled with indium-111, is specifically designed for tumour imaging, in particular of tumours in the abdomen (M-D-D-I Reports (“The Gray Sheet”) Nov. 2, 1992, p. 14).
It has been observed, however, that various frequently occurring malignant tumours, such as ductal pancreatic adenocarcinomas, cannot be detected and localized by using radiolabelled octreotide.
REFERENCES:
patent: 95/22341 (1995-08-01), None
Ishizuka et al., Annal of Surgery, 217, pp,. 439-446, 1993.
Hartley Michael G.
Mallinckrodt Inc.
Rothwell Figg Ernst & Manbeck
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