Surgery – Liquid medicament atomizer or sprayer
Patent
1997-02-04
1998-10-13
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
12820022, 12820423, A61M 1100
Patent
active
058197265
ABSTRACT:
A method of treating patients suffering from a respiratory disease using a programmable, hand-held, self-contained drug dispensing device is disclosed. A patient's inspiratory flow rate is measured and a determination is made of a typical and preferred rate and volume for the release of respiratory drug. To obtain repeatability in dosing the drug is repeatedly released at the same rate and volume. To maximize the amount of drug delivered based on the amount released the drug is released at a rate of from about 0.10 to about 2.0 liters/second and (2) a volume of about 0.15 to about 0.8 liters. Parameters such as rate, volume, and particle size of the aerosolized formulation are adjusted to obtain repeatable dosing of the maximum amount of drug to the desired area of the lung. Lung function is measured and use parameters are adjusted in order to improve lung function.
REFERENCES:
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3991304 (1976-11-01), Hillsman
patent: 4361401 (1982-11-01), Smith et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4627432 (1986-12-01), Newell et al.
patent: 4686231 (1987-08-01), Bender et al.
patent: 4877989 (1989-10-01), Drews et al.
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5167506 (1992-12-01), Kilis et al.
patent: 5363842 (1994-11-01), Mishelerich et al.
patent: 5558085 (1996-09-01), Rubsamen et al.
Newman et al.; "How Should A Pressurized B-Adrenergic Bronchodilator Be Inhaled?", (1981), Eur. J. Respir. Dis., 62, 3-21.
Camp, J.P., "Patient-Controlled Analgesia",1991, AFP Clinical Pharmacology, 44:2145-2150.
Colthorpe, P. et al., "The pharmacokinetics of Pulmonary-Delivered Insulin:A comparison of intratracheal and aerosol administration to the rabbit", 1992, Pharmaceutical Research, 9:764-768.
Daman, H.R., "Pulmonary function testing:Use of the peak expiratory flow rate in an out-patient or office setting", 1984, Journal of Asthma, 21:331-337.
Evans, R. et al., "National trends in the morbidity and mortality of asthma in the US", 1987, Chest, 91(Supp.):65S-74S.
Gourlay, G.K. et al., "Fetanyl blood concentration-analgesic response relationship in the treatment of postoperative pain", 1988, Anesth. Analg. 67:329-337.
Jackson, R. et al., "International trends in asthma mortality: 1970 to 1985", 1988, Chest, 94:914-919.
Jaffe, A.B. et al., Rats self-administer sufentanil in aerosol form.
Janson-Bjerklie, S. et al., "Effect of peak flow information on patterns of self-care in adult asthma", 1988, Heart & Lung, 17:543-549.
Kohler, D., "Aerosols for Systemic Treatment", 1990, Lung, Suppl.:677-684.
Lauber, B.L. et al., "Deposition, Clearance, and Effects in the Lung", Journal of Aerosol Medicine, 4:286.
Lehmann, K.A. et al., "Transdermal fentanyl for the treament of pain after major urological operations", 1991, Eur. J. Clin. Pharmacol. 41:17-21.
Malo, J. et al., Four-times-a-day dosing frequency is better than a twice-a-day regimen in subjects requiring a high-dose inhaled steroid, budesonide, to control moderate to severe asthma, 1989, Am. Rev. Respir. Dis. 140:624-628.
Mather, J.E., "Pharmacokinetics and patient-controlled analgesia(*)", 1992, Acta Anaesthesiologica Belgica 43:5-20.
Miller, R., "Anaesthesia", (2nd Edition), 1986, Churchill Livingstone, 1:762.
Moses, A.C. et al., Insulin administered intranasally as an insulin-bile salt aerosol-Effectiveness and Reproducibility in Normal and Diabetic Subjects, 1983, Diabetes, 32:1040-1047.
Newman, S.P. et al., "Deposition of pressurized aerosols in the human respiratory tract", 1981, Thorax, 36:52-55.
Newman, S.P. et al., "How should a pressurized .beta.-adrenergic bronchodilator be inhaled?", 1981, Eur. J. Respir. Dis. 62:3-21.
Newman, S.P. et al., "Deposition of pressurized suspension aerosols inhaled through extension devices", 1981, Am. Rev. Respir. Dis. 124:317-320.
Newman, S.P., "Deposition and Effects of Inhalation Aerosols", 1983, (2 ed.), Churchill Livingstone.
Newman, S.P., "Aerosol deposition in automatic dosimeter nebulization", 1987, Eur. J. Respir. Dis. 71:145-152.
Nowak, R. et al., Comparison of peak expiratory flow and FEV.sub.1 admission criteria for acute bronchial asthma, 1982, Annals of Emergency Medicine, 11:64-69.
Rapp, R.P. et al., Patient-controlled analgesia:A review of effectiveness of therapy and an evaluation of currently available devices, 1989, DICP, The Annals of Pharmacotherapy 23:899-904.
Rosenberg, M., "Patient-controlled analgesia", 1992, J. Oral Maxillofac. Surg. 50:386-389.
Rowbotham, D.J. et al., "A disposable device for patient-controlled analgesia with fentanyl",1989, Anaesthesia, 44:922-924.
Ryder, E., "The history of patient-controlled analgesia", 1991, Journal of Intravenous Nursing 14:372-381.
Salzman, R., "Intranasal aerosolized insulin mixed-meal studies and long-term use in type 1 diabetes",1985, New England Journal of Medicine, 213:1078-1084.
Sears et al., "Increasing asthma mortality-fact or artifact?", 1988, Journal of Allergy and Clinical Immunology, 82:957-960.
Shade, P., "Patient-controlled analgesia:can client education improve outcomes?", 1992, Journal of Advanced Nursing, 17:408-413.
Shim, Chang et al., "Evaluation of the severity of asthma:Patients versus physicians", American Journal of Medicine, 68:11-13.
Smythe, M., "Patient-controlled analgesia:A review", 1992, Pharmacotherapy, 12:132-143.
Spitzer, W.O. et al., "The Use of .beta.-agonists and the risk of death and near death from asthma", 1992, N. Engl. J. Med. 326:501-506.
Wigley, F.M. et al., "Insulin across respiratory mucosae by aerosol delivery", 1971, Diabetes 20:552-556.
William, Jr., H., "Expiratory flow rates:Their role in asthma therapy", 1982, Hospital Practice 10:95-110.
Yoshida, H. et al., "Absorption of insulin delivered to rabbit trachea using aerosol dosage form", 1979, J. Pharmaceutical Sciences, 68:670-671.
Lloyd Lester John
Rubsamen Reid M.
Aradigm Corporation
Bozicevic Karl
Lewis Aaron J.
LandOfFree
Method for the delivery of aerosolized drugs to the lung for the does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for the delivery of aerosolized drugs to the lung for the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for the delivery of aerosolized drugs to the lung for the will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-303176