Method for the delivery of a biologically active agent

Details Method for the delivery of a biologically active agent Method for the delivery of a biologically active agent

2005-03-01

2005-03-01

Page, Thurman K. (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S434000, C424S436000, C424S451000, C424S474000, C424S045000, C514S944000

Reexamination Certificate

active

06861066

ABSTRACT:
A method of manufacturing a stable nanosuspension for delivery of a biologically active agent into the bloodstream of a subject is disclosed. A microfluidizable mixture is initially formed and processed via a microfluidization process to form the stable nanosuspension, which may be administered via the buccal mucosa or other suitable routes of administration. This product demonstrates increased bioavailability, enhanced period of onset, and enhanced stability for a controlled-release product.

REFERENCES:
patent: 4946870 (1990-08-01), Partain, III et al.
patent: 5056511 (1991-10-01), Ronge
patent: 5271944 (1993-12-01), Lee
patent: 5681600 (1997-10-01), Antinone et al.
patent: 5858410 (1999-01-01), Muller et al.
patent: 5891465 (1999-04-01), Keller et al.
patent: 5981591 (1999-11-01), Deihl
patent: 20030072801 (2003-04-01), Curatolo et al.
International Journal of Pharmaceutics, Gandhi et al.; “Mechanisms of penetration enhancement for transbuccal delivery of salicylic acid”, vol. 85, (1992), pp. 129-140.*
International Journal of Pharmaceutics, Aungst et al,; “Comparison of the effects of various transmucosal absorption promoters on buccal insulin delivery”, vol. 53, 3, (1989), pp. 227-235.
Journal of Pharmaceutical Sciences, Ch'ng et al.; “Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery II”, vol. 74, 4, (1985), pp. 399-405.

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