Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Reexamination Certificate
2006-08-08
2006-08-08
Weber, Jon (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
C530S362000, C530S364000, C530S402000, C530S412000, C530S417000, C530S418000, C530S419000, C530S421000, C530S829000, C530S830000, C514S002600
Reexamination Certificate
active
07087719
ABSTRACT:
The present invention relates to the purification and production of human albumin from various sources through crystallization and repeated crystallization. Basic features of the invented process include providing specific reaction conditions and precipitating reagents to maximize albumin crystallization. Solubility diagrams are utilized as the basis for process control of the invented method. The current invention specifically controls phosphate concentration, pH and temperature to precisely guide crystallization kinetics and crystal yield.
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Couto Daniel E.
Fulton Scott P.
Uotila Sinikka
Visuri Kalevi
GTC Biotherapeutics, Inc.
Mohamed Abdel A.
Olsen Byron V.
Weber Jon
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