Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1997-10-02
1999-10-12
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530403, 530406, 5303915, 5303919, 4241301, 4241781, 4241841, 4241931, 4241941, 42419611, 42419711, C07K 107, A61K 3900, A61K 3912
Patent
active
059657146
ABSTRACT:
Disclosed and claimed are a method for the covalent attachment of poly- and oligosaccharides to protein molecules via hydrogen peroxide depolymerization of the polysaccharide units, followed by attachment of the depolymerized polysaccharide chain to the amino acid groups of a protein of interest through a linker molecule, and products therefrom, and methods for using the products.
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Dick. W.E. Jr. and Beurret. M. Conjugate Vaccines. Contrib. Microbiol. Immunol. (1989) 10. pp. 48-114. Cruse, J.M. and Lewis, R.E. Jr. eds. Basel, Karger.
Santosham, M. (1993) Vaccine 11: 552-557.
Isbell, H.S. and Frush, H.L. (1987) Carbohydrate Research 161: 181-193.
Yalpani, M. Polysaccharides Syntheses, Modifications and Structure/Property Relations (1988) Elsevier, Amsterdam. pp. 370-388.
Park, J.T. and Johnson, M.J. (1949) J. Biol. Chem. 181:149.
Achutamurthy Ponnathapura
Connaught Laboratories Inc.
Howe Timothy R.
Smith G. Kenneth
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