Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1998-10-28
2000-04-04
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435148, 435129, 435135, C12P 724, C12P 1302, C12P 762
Patent
active
060460431
ABSTRACT:
The present invention provides a general biocatalyst for transforming saturated carbonyl compounds to their .alpha.,.beta.-unsaturated analogs. The transformation is regio- as well as stereoselective. These catalysts are useful in the chiral resolution of carbonyl compounds as well as in the development of libraries of small molecules to screen as potential drug candidates.
REFERENCES:
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Murthy et al., "Syntheses and Applications of Flavin Analogs as Active Site Probes for Flavoproteins," Methods in Enzymology, vol. 280, 1997, pp. 436-460.
Vaz et al., "Old Yellow Enzyme: Aromatization of Cyclic Enones and the Mechanism of a Novel Dismutation Reaction", Biochemistry 34 : 4246-56, (1995).
Massey Vincent
Murthy Yerramilli V. S. N.
Hofer Brinks
Saucier Sandra E.
The Regents of the University of Michigan
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