Method for the conversion of carbonyl compounds to their .beta.-

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound

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435148, 435129, 435135, C12P 724, C12P 1302, C12P 762

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active

060460431

ABSTRACT:
The present invention provides a general biocatalyst for transforming saturated carbonyl compounds to their .alpha.,.beta.-unsaturated analogs. The transformation is regio- as well as stereoselective. These catalysts are useful in the chiral resolution of carbonyl compounds as well as in the development of libraries of small molecules to screen as potential drug candidates.

REFERENCES:
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Murthy et al. "Synthesis And Properties Of 8-CN-Flavins And Reconstituted Flavoproteins," Abstract No. 046, 212.sup.th ACS National Meeting, mailed to public Aug. 8, 1996.
Murthy et al., "Syntheses and Applications of Flavin Analogs as Active Site Probes for Flavoproteins," Methods in Enzymology, vol. 280, 1997, pp. 436-460.
Vaz et al., "Old Yellow Enzyme: Aromatization of Cyclic Enones and the Mechanism of a Novel Dismutation Reaction", Biochemistry 34 : 4246-56, (1995).

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