Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing
Reexamination Certificate
2005-01-18
2005-01-18
Shippen, Michael L. (Department: 1621)
Organic compounds -- part of the class 532-570 series
Organic compounds
Oxygen containing
C568S627000, C568S646000
Reexamination Certificate
active
06844471
ABSTRACT:
A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I)wherein R1, R2, and R3are the same or different and independently represent (C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl, allyl, vinyl, silyl, formyl, acyl, aryl(C1-C4)alkyl or substituted aryl(C1-C4)alkyl group. The present invention also provides a process for the conversion of (E)-(3,5-disubstituted phenyl-2-(4-substituted phenyl)ethene of general formula (I) to E-resveratrol of formula (III).
REFERENCES:
patent: 2311093 (1943-02-01), Serini et al.
patent: 2346049 (1944-04-01), Rohrmann
patent: 6048903 (2000-04-01), Toppo
patent: WO0160774 (2001-08-01), None
Kim, J. Med.Chem., vol. 45, pp. 160-164 (Published on Web Dec. 7, 2001).
Andrew Gnanaprakasam
Deshpande Pandurang Balwant
Palanisamy Senthil Kumar Udayampalayam
Oliff & Berridg,e PLC
Orchid Chemicals and Pharmaceuticals Limited
Shippen Michael L.
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