Method for the continuous production of tetra-substituted ureas

Details Method for the continuous production of tetra-substituted ureas Method for the continuous production of tetra-substituted ureas

2006-05-30

2006-05-30

O'Sullivan, Peter (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S057000, C564S061000

Reexamination Certificate

active

07053244

ABSTRACT:
The invention relates to a process for the preparation of tetrasubstituted ureas by reaction of the corresponding amines with phosgene in the presence of an aqueous inorganic base at a temperature in the range from 0 to 150° C., which comprises:feeding the corresponding amine, the phosgene and the aqueous inorganic base on average continuously to the reaction apparatus,forming a two-phase system in the reaction apparatus through the choice of the tetrasubstituted ureas to be prepared, through the mixing ratios of the substances and substance mixtures to be fed in, through the temperature during the reaction and, where appropriate, through the feed of an organic solvent which is not completely miscible with water, anddischarging the reaction mixture on average continuously from the reaction apparatus.

REFERENCES:
patent: 3681457 (1972-08-01), Babad
patent: 3904602 (1975-09-01), Somlo
patent: 5132423 (1992-07-01), Brunelle et al.
patent: 0248 220 (1987-12-01), None
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patent: WO 94/22939 (1994-10-01), None
International Search Report, Oct. 2003, PCT/EP20003/007083.
Ullmann's Encyclopedia of Industrial Chemistry, 6thEdition, 2000 Electronic Release, Urea-Urea Derivatives-Meessen, et al., pp. 1-10.
W.A. Skinner et al., J. Pharm. Sci 68, vol. No. 3, pp. 391-392, Mar. 1979; Topical Mosquito Repellents XIII; N-Substituted Ureas and Cyclic Ureas.

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