Method for the commercial production of helminths antigens

Details Method for the commercial production of helminths antigens Method for the commercial production of helminths antigens

1985-02-21

1986-02-04

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

4351721, 119 1, 424 88, 424 95, 436543, C12P 2100, C12N 1500, A01K 4500, A61K 3900

Patent

active

045686394

ABSTRACT:
An easily cultured worm is genetically modified such that its surface antigens on its modified form are immunologically identical to the surface antigens of a parasitic worm. Specifically, C. elegans is genetically modified to produce antigens corresponding to the antigens of D. immitis which causes heartworm infection. The antigens derived from the easily cultured worm are used to form a vaccine and/or diagnostic.

REFERENCES:
patent: 4396600 (1983-08-01), Messiner et al.
Desowitz et al, Journal of Helminthology, vol. 50, pp. 53-57 (1976).
Hirsh et al, Developmental Biology, vol. 49, pp. 220-235 (1976).
Lew et al, Environ Mutagen, p. 265 (1980).
Lew et al, Environ Mutagen, p. 346 (1981).
Edgar et al, Science, vol. 198, pp. 1285 & 1286 (1977).
Emmons et al, PNAS, vol. 76, pp. 1333-1337, Mar. 1979.
Filijev, Smithsonian Miscellaneous Collections, vol. 89, No. 6, Mar. 20, 1934.

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