Chemistry: physical processes – Physical processes – Crystallization
Patent
1976-06-11
1978-06-20
Wolk, Morris O.
Chemistry: physical processes
Physical processes
Crystallization
23230B, 73 611C, 210 31C, G01N 3108
Patent
active
040959503
ABSTRACT:
Method for the chromatographic analysis of a technetium-containing mixture of bound, reduced technetium; unbound, reduced technetium; and, free pertechnetate. A portion of the mixture is spotted on a chromatographic adsorbent, preferably cellulose-fiber paper, and is developed with an aqueous salt solution, preferably comprising sodium chloride and/or sodium pyrophosphate. The developed chromatogram has an isolated zone in which the unbound, reduced technetium is located. Simultaneously therewith, a second chromatogram is developed utilizing a suitable liquid organic solvent, preferably comprising a mixture of acetone and acetic acid. The developed chromatogram has an isolated zone in which the free pertechnetate is located. Radioactive measurements are made and the amounts of unbound, reduced technetium and of free pertechnetate are determined as proportions of total technetium. The amount of bound, reduced technetium may then be readily calculated. An elutable or chromatographic dye is preferably located on the adsorbent prior to development. The dye separates into colored regions which serve to indicate the completion of development, the approximate area of separation between the regions of the technetium states and the propriety of the technique used in performing the analysis.
REFERENCES:
patent: 3046779 (1962-07-01), Coleman
patent: 3725295 (1973-04-01), Eckelman et al.
patent: 3873680 (1975-03-01), Jackson et al.
patent: 3914174 (1975-10-01), Fuchs
Eckelman et al., "Analytical Pitfalls with Techetium-99m-labeled Compounds", Chemical Abstracts, vol. 77, 1972, No. 2428J.
Bio-Dynamics Inc.
Turk Arnold
Wolk Morris O.
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