Method for the automatic control of the amount of active...

Details Method for the automatic control of the amount of active... Method for the automatic control of the amount of active...

2007-04-05

2008-12-30

Rodriguez, Paul L (Department: 2123)

Data processing: generic control systems or specific application

Specific application, apparatus or process

Product assembly or manufacturing

C425S148000, C425S149000

Reexamination Certificate

active

07471992

ABSTRACT:
Method for the automatic control of the amount of active ingredient of tablets during the production in a rotary tablet press, which has a die table with die bores, upper and lower punches assigned to the die bores, a filling station, a metering cam for the lower punches in the filling station, at least one pressing station with at least one upper and one lower pressing roller, wherein at least the lower pressing roller is adjustable with respect to the other pressing roller by means of a pressing roller adjustment equipment, a metering cam adjustment equipment for height adjustment of the metering cam, a compression force measuring equipment at the pressing station, a control and operating computer and an active ingredient measuring equipment, characterized by the following procedural steps: during the tablet production, the amount of active ingredient of tablets is measured and values for the amount of active ingredient are compared with a predetermined desired active ingredient value in the control and operating computer, and the metering cam is adjusted in accordance with the deviation of the measured amount of active ingredient from the desired active ingredient value.

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“Nondestructive and ON-line Monitoring of tablets using light-Induced Fluorescence Technology”, Chee Kong Lai, AAPS PharmSciTech 2004.

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