Chemistry: physical processes – Physical processes – Crystallization
Patent
1979-04-09
1980-12-02
Marantz, Sidney
Chemistry: physical processes
Physical processes
Crystallization
23915, 310312, 324 71R, 422 57, 422 61, 422 69, 424 12, G01N 3354, H01L 4100
Patent
active
042368936
ABSTRACT:
A method and article for the determination of a particular subclass of antibody, e.g., IgA, IgE, IgM, etc., are disclosed. The method utilizes a piezoelectric oscillator having bound to the surface thereof an antigen specific for the antibody being determined. The antigen-coated oscillator is exposed to a solution containing an unknown amount of the antibody. After the antibody in the solution has attached to the antigen on the oscillator, the oscillator is exposed to a substance (sandwiching substance) which selectively binds to a specific subclass of the antibody being determined. The frequency of the oscillator is measured before and after exposure to the sandwiching substance. The change in frequency is related to the amount of the subclass of antibody bound to the oscillator, and the amount of the subclass of antibody in the solution can be quantified by reference to a standard curve.
REFERENCES:
patent: 3720760 (1973-03-01), Bennich
patent: 3966898 (1976-06-01), Sjoquist
patent: 4092114 (1978-05-01), Buck
A. Shons et al., J. Biomed. Mater. Res., 6, 565-570, (1972).
Alexander Cruzan
Bates Carolyn A.
Marantz Sidney
Minnesota Mining and Manufacturing Company
Sell Donald M.
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