Method for the acylation of the 7-amino group of the cephalospor

Details Method for the acylation of the 7-amino group of the cephalospor Method for the acylation of the 7-amino group of the cephalospor

1993-07-07

1995-08-15

Rizzo, Nicholas

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

540222, 540227, 540225, C12P 3500

Patent

active

054418747

ABSTRACT:
A method for the acylation of the 7-amino group of the cephalosporanic ring, according to which a 7-ACA amino thiazolyl protected adduct is prepared by acylating said amino group by an aminothiazolyl acetic acid whose amino group has been protected by a phenyl acetyl or a phenoxy acetyl group, the amino group being then deprotected by aqueous hydrolysis in the presence of penicillin G amidase or respectively penicillin V amidase.

REFERENCES:
patent: 3749641 (1973-07-01), Takahashi et al.
patent: 3930949 (1976-01-01), Kutzbach et al.
patent: 4091245 (1978-05-01), Bouzard et al.
patent: 4517361 (1985-05-01), Numata et al.
patent: 5292733 (1994-03-01), Kim et al.

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