Method for the acylation of the 7-amino group of the cephalospor

Details Method for the acylation of the 7-amino group of the cephalospor Method for the acylation of the 7-amino group of the cephalospor

1995-05-01

1997-08-05

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540225, 540227, 540228, C07D50124

Patent

active

056544251

ABSTRACT:
A method for the acylation of the 7-amino group of the cephalosporanic ring, according to which a 7-ACA amino thiazolyl protected adduct is prepared by acylating said amino group by an aminothiazolyl acetic acid whose amino group has been protected by a phenyl acetyl or a phenoxy acetyl group, the amino group being then deprotected by aqueous hydrolysis in the presence of penicillin G amidase or respectively penicillin V amidase.

REFERENCES:
patent: 4500526 (1985-02-01), Imae et al.
patent: 4507487 (1985-03-01), Kamachi et al.

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