Method for the acylation of heterocyclic compounds

Details Method for the acylation of heterocyclic compounds Method for the acylation of heterocyclic compounds

1980-04-11

1981-03-03

Raymond, Richard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603262, 26032637, 26032646, 2603265J, 2603458R, 2603459R, 2603478, 546262, 546314, 546328, 549 14, 549 59, 549 70, 549 72, 549 73, C07D30746

Patent

active

042540437

ABSTRACT:
A process is disclosed for the single step acylation of heterocyclic aryl compounds of the formula: ##STR1## wherein X is the radical selected from the group --N.dbd., --NH--, --O-- and --S-- and Y is the radical selected from the group --CH-- and --CH.dbd.CH-- by treatment with a compound of the formula ##STR2## wherein R is C.sub.1 to C.sub.12 alkylene; Z is selected from the group hydrogen, cyano, halo, C.sub.1 to C.sub.6 alkoxy, C.sub.1 to C.sub.6 alkoxy carbonyl, unsubstituted or substituted phenyl, the substituents selected from the group C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, cyano, halo and trifluoromethyl; and n' is the integer 1 or 2.

REFERENCES:
patent: 2492629 (1949-12-01), Hartough et al.
patent: 2963488 (1960-12-01), Webb

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