Method for testing the differentiation status in pancreatic cell

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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514 2, 514 44, 530350, C12Q 168, A61K 3700, A61K 4800, C07K 1300

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active

060716975

ABSTRACT:
The present invention relates to a novel method for testing the developmental status in pancreatic cells of a mammal. The present invention further relates to applications in the medical field that directly arise from the method of the invention. Additionally, the present invention relates to transgenic mammals comprising at least one inactivated Pax4 allele and optionally at least one inactivated Pax6 allele.

REFERENCES:
Paillard. Human Gene Therapy, 8:2009-2010, Nov. 1997.
Correll et al. Human Gene Therapy 1:227-287, 1990.
Orkin et al. Report and Recommendations of the Panel to Assess the NIH Intment in Research on Gene Therapy pp. 1-38, Dec. 1995.
Walther et al. Genomics 11:424-434, Oct. 1991.
Tamura et al. Cytogenet Cell Genet. 66:132-134, Mar. 1994.

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