Method for testing the ability of an agent to inhibit...

Details Method for testing the ability of an agent to inhibit... Method for testing the ability of an agent to inhibit...

2006-05-31

2009-12-01

Saucier, Sandra (Department: 1651)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C536S001110

Reexamination Certificate

active

07625999

ABSTRACT:
The present invention provides a method for testing an agent for its ability to inhibit binding between fibroblast growth factor (FGF) and heparan sulfate, comprising the steps of: interacting in solution immobilized FGF on a solid support with the agent and labeled heparan sulfate, and detecting the presence or absence of label in the solution remote from the solid support.

REFERENCES:
patent: 4859581 (1989-08-01), Nicolson et al.
patent: 5206223 (1993-04-01), Vlodavsky et al.
patent: 5332812 (1994-07-01), Nicolson et al.
patent: 5362641 (1994-11-01), Fuks et al.
patent: 5795860 (1998-08-01), Witt et al.
patent: 5849722 (1998-12-01), Habuchi et al.
patent: 5891655 (1999-04-01), Ornitz
patent: 5968822 (1999-10-01), Pecker et al.
patent: 6190875 (2001-02-01), Ben-Artzi et al.
patent: 6207402 (2001-03-01), Freeman et al.
patent: 199 55 803 (2001-05-01), None
patent: 0 244932 (1987-11-01), None
patent: S62-265998 (1987-11-01), None
patent: P H09-40581 (1997-02-01), None
patent: WO 93/19096 (1993-09-01), None
patent: WO 94/20512 (1994-09-01), None
patent: WO 95/04158 (1995-02-01), None
patent: WO 98/03638 (1998-01-01), None
patent: WO 99/40207 (1999-08-01), None
patent: WO 99/43830 (1999-09-01), None
patent: WO 00/03036 (2000-01-01), None
patent: WO 00/77241 (2000-12-01), None
Lider et al., J. Clin. Invest., 83, pp. 752-756 (1989).
Willenberg et al., J. Immunol., 140, pp. 3401-3405 (1988).
Hemmila et al., Anal. Biochem., 137, pp. 335-343 (1984).
Hemmila et al., Drug Discovery Today, 2, pp. 373-381 (1997).
Vlodavsky, et al., Invasion Metastasis, 14, pp. 290-302 (1994).
Freeman, C. & Parish, C.R., Biochem J., 325, pp. 229-23 (1997).
Parish, C.R., et al., Cancer Res., 59, pp. 3433-3441 (1999).
Nakajima, M., et al., Anal Biochem., 157 91), pp. 162-17 (1986).
Oosta, G.M., et al., Biol. Chem., 257 (19), pp. 11249-11255 (1982).
Sewell, R.F., et al., Biochem J., 264 (3), pp. 777-783 (1989).
Maccaranna, M., et al., 268 (32), pp. 23898-23905 (1993).
Aviezer, D., et al., J. Biomol. Screen., 6(3), pp. 171-177 (2001).
Kardami, et al., Developmental Biology, vol. 126, pp. 19-28 (1988).
Foxall, et al., Journal of Cellular Physiology, vol. 168, pp. 657-667 (1996).
Chernousov & Carey, Journal of Biological Chemistry, vol. 268, pp. 16810-16814 (1993).
Berman, et al., Journal of Biological Chemistry, vol. 274, pp. 36132-36138 (1993).
Foxall et al., Anal. Biochem., 231, pp. 366-373 (1995).
Toyoshima et al., J. Biol. Chem., 274, pp. 24153-21460 (1999).
Yamane, Y. et al,Jour. Of Bio. Chem., 273(13) 7375-7381 (1998).
Germani, Y. et al,Jour. Of Immuno. Methods, 146, 25-32 (1992).

Affiliated with

Also associated with

Rating

Method for testing the ability of an agent to inhibit... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for testing the ability of an agent to inhibit..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for testing the ability of an agent to inhibit... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4099721