Method for testing of embryotoxicity on chicken embryo

Details Method for testing of embryotoxicity on chicken embryo Method for testing of embryotoxicity on chicken embryo

1977-03-16

1979-05-08

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

195 17, 195 18, 424 3, A61K 2900, G01N 3300, G01N 3308

Patent

active

041536762

ABSTRACT:
Method for testing of the embryotoxicity in the chicken embryo consists in reading the response of caudal morphogenetic system (CMS) of a chicken embryo to the presence of the tested substance in subgerminal fluid. The function of the caudal morphogenetic system is evaluated 24 hours after application by a simple quantitative parameter -- the length of a newly-formed part of the trunk. The substance, which interferes with some of the basic morphogenetic processes, slows down, stops or modifies the formation of the shape of the caudal part of trunk. Considering that the quantitative parameter is used as the index of the CMS function, each member of the experimental set presents information, not only the dead and malformed embryos as in classical methods. The second part of the test, i.e. the more precise determination of the beginning of the direct embryotoxicity range, serves above all for disclosure of the effect of the tested substance on the circulation system of the embryo and smooth muscles of faetal membranes. The testing according to this method may be used in pharmaceutical productions and plants, further in chemical productions and for environmental monitoring.

REFERENCES:
jelinek, Folia Morphologica, vol. XIX (1971), pp. 60-137, photo, 2 pages.
Jelinek, Folia Morphologica, vol. XVIII (1970), pp. 125-137, photo, 2 pages.
Klika, Folia Morphologica, vol. XVII (1969), pp. 29-40, photo, 6 pages.

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