Method for testing for the presence of metastatic tumor cells

Details Method for testing for the presence of metastatic tumor cells Method for testing for the presence of metastatic tumor cells

1991-07-29

1995-01-03

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 724, 435 72, 435 13, 435960, 435 733, 435 734, 436501, 436 63, 436 64, 436813, G01N 3353, G01N 33574, G01N 3386

Patent

active

053786076

ABSTRACT:
A method of testing for the presence of tumor cells which are metastatic based upon the presence of Human Leukocyte Antigen (HLA) is described. In the test a protein which selectively binds the HLA is used to determine the presence of excess HLA which is a characteristic of the tumor cells. The preferred protein is a bacterial enterotoxin, preferably the enterotoxin A (SEA) produced by Staphylococcus aureus.

REFERENCES:
Natali, P. G., et al, PNAS, vol. 86, No. 17, pp. 6719-6723 (1989).
Johnson, J. P., et al, Invasion Metastasis, vol. 9, pp. 338-350 (1989).
Herlyn, M., et al., Leuk. Res., vol. 8, No. 3, pp. 323-334 (abstract only) 1984.

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