Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-10-17
2006-10-17
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100
Reexamination Certificate
active
07122318
ABSTRACT:
The present invention provides a system for testing the influence of a drug on integrin expression, which comprises measuring an integrin expression level in platelets of an individual to which the drug is administered and, based on the measured expression amount, determining what effect the drug has on integrin expression in cells other than platelets.
REFERENCES:
patent: 5721246 (1998-02-01), Yoshino et al.
patent: 5843906 (1998-12-01), Chandrakumar et al.
patent: 6096707 (2000-08-01), Heino et al.
patent: 1 074 542 (2001-02-01), None
patent: 1 258 252 (2002-11-01), None
patent: WO 98/44797 (1998-10-01), None
patent: WO 99/02551 (1999-01-01), None
patent: WO 00/41469 (2000-07-01), None
patent: WO 01/56607 (2001-08-01), None
patent: WO 02/066073 (2002-08-01), None
Trikha, et al., “Human Prostate Carcinoma Cells Express Functional αIIbβ Integrin”,Cancer Research, 56: 5071-5078, 1996.
Verheul, et al., “Vascular Endothelial Growth Factor-Stimulated Endothelial Cells Promote Adhesion and Activation of Platelets”,Blood, 96: 4216-4221, 2000.
Verheul, et al., “Platelet and Coagulation Activation with Vascular Endothelial Growth Factor Generation in Soft Tissue Sarcomas”,Clinical Cancer Research, 6: 166-171, 2000.
Baatout, et al., “Protein Content and Number of Nucleolar Organizer Regions are Enhanced During Phorbol Ester-Induced Differentiation of Cultured Human Megakaryocytic Cells”,Anticancer Research, 19: 3229-3236, 1999.
Braun, et al., “Monoclonal Antibody Therapy with Edrecolomab in Breast Cancer Patients: Monitoring of Elimination of Disseminated Cytokeratin-Positive Tumor Cells in Bone Marrow”,Clinical Cancer Research, 5: 3999-4004, 1999.
Brooks, et al., “Requirement of Vascular Integrin αvβ3for Angiogenesis”, Science, 264: 569-571, 1994.
Davis, et al., “An α2β1 Integrin-Dependent Pinocytic Mechanism Involving Intracellular Vacuole Formation and Coalescence Regulates Capillary Lumen and Tube Formation in Three-Dimensional Collagen Matrix”,Experimental Cell Research, 224: 39-51, 1996.
Denis, et al., “Pharmacodynamics and Pharmacokinetics of Bicalutamide: Defining an Active Dosing Regimen”,Urology, 47: 26-32, 1996.
Eliceiri, et al., “Adhesion Events in Angiogenesis”,Current Opinion in Cell Biology, 13: 563-568, 2001.
Friedlander, et al., “Definition of Two Angiogenic Pathways by Distinct αvIntegrins”,Science, 270: 1500-1502, 1995.
Ikeda, et al., “Inhibition of Gelatinolytic Activity in Tumor Tissues by Synthetic Matrix Metalloproteinase Inhibitor: Application of Film in Situ Zymography”,Clinical Cancer Research, 6: 3290-3296, 2000.
Nieuwenhuis, et al., “Human Blood Platelets Showing no Response to Collagen Fail to Express Surface Glycoprotein Ia”Nature, 318: 470-472, 1985.
Owa, et al., “Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle”,J. Med. Chem. 42: 3789-3799, 1999.
Ozawa, et al., “E7070, A Novel Sulphonamide Agent with Potent Antitumour Activity in Vitro and In Vivo”,European Journal of Cancer, 37: 2275-2282, 2001.
Senger, et al., “Angiogenesis Promoted by Vascular Endothelial Growth Factor: Regulation Through α1β1and α2β1 Integrins”Proc. Natl. Acad. Sci. USA, 94: 13612-13617, 1997.
Yoshino, et al., “Novel Sulfonamides as Potential, Systemically Active Antitumor Agents”,J. Med. Chem. 35: 2496-2497, 1992.
Zutter, et al., “The Megakaryocyte/Platelet-Specific Enhancer of the α2β1 Integrin Gene: Two Tandem AP1 Sites and the Mitogen-Activated Protein Kinase Signaling Cascade”, Blood, 93(5): 1600-1611, 1999.
Zutter, et al., “Regulation of α2Integrin Gene Expression in Cells with Megakaryocytic Features: A Common Theme of Three Necessary Elements”,Blood, 86(8): 3006-3014, 1995, May 18, 2006.
Zutter, et al., “Binding of Phosphorylated Sp1 Protein to Tandem Sp1 Binding Sites Regulates α2Integrin Gene Core Promoter Activity”,Blood, 90(2): 678-689, 1997.
Zutter, et al., “The Human α2Integrin Gene Promoter, Identification of Positive and Negative Regulatory Elements Important for Cell-Type and Developmentally Restricted Gene Expression”,The Journal of Biological Chemistry, 269(1): 463-469, 1994.
International Search Report issued for corresponding PCT application PCT/JP02/01562.
Funahashi Yasuhiro
Hata Naoko
Ono Naoto
Senba Taro
Wakabayashi Toshiaki
Choate, Hall & Stweart, LLP
Eisai Co. Ltd.
Herschbach Jarrell Brenda
Lyon Charles E.
Whisenant Ethan
LandOfFree
Method for testing effect of angiogenesis inhibitor via... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for testing effect of angiogenesis inhibitor via..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for testing effect of angiogenesis inhibitor via... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3708824