Method for temporarily inhibiting or deactivating serine hydrola

Details Method for temporarily inhibiting or deactivating serine hydrola Method for temporarily inhibiting or deactivating serine hydrola

1992-03-04

1994-05-24

Naff, David M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Enzyme inactivation by chemical treatment

435188, 435183, 435219, C12N 999, C12N 9100, C12N 996

Patent

active

053148150

ABSTRACT:
Phenacyl phosphonate adducts of serine hydrolases temporarily inhibit or inactivate the serine hydrolases. The serine hydrolases are activated by intramolecularly catalyzed dephosphonylation of the adduct over a period of time. Half-lives for dephosphonylation in the range of about 30 to 500 minutes have been observed at physiological pH's.

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