Method for targeted and controlled release of drugs in the intes

Details Method for targeted and controlled release of drugs in the intes Method for targeted and controlled release of drugs in the intes

1992-11-06

1999-05-04

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424451, 424457, 424458, 424462, 424464, 424490, 424496, 424497, A61K 916, A61K 924, A61K 954

Patent

active

059002522

ABSTRACT:
The object of the present invention is to obtain a targeted and controlled release of drugs, the pharmacological action and absorption of which takes place in the intestine and in particular in the ileum and in the colon.
To achieve this objective the drug is coated with two membranes, one having pH dependent solubility and the other insoluble but permeable to intestinal juices.
As long as the coated drug remains in the stomach and in the upper part of the intestinal tract, that is as long as the pH is lower than 5.5, it is not released.
Only when it reaches an environment with a higher pH (small intestine and/or colon), the pH dependent membrane dissolves and the release of the drug can begin.
From this moment the second membrane, pH-independent but permeable to intestinal juices, carries out its action which is to slow down and control the dissolution of the drug in the small intestine-colon tract.

REFERENCES:
patent: 4432966 (1984-02-01), Zeitoun et al.
patent: 4503030 (1985-03-01), Edgren et al.
patent: 4533562 (1985-08-01), Ikegami et al.
patent: 4797287 (1989-01-01), Pich et al.
patent: 4800087 (1989-01-01), Mehta
patent: 4808416 (1989-02-01), Hata et al.
patent: 4925676 (1990-05-01), Ghebre-Sellasie et al.
patent: 4983401 (1991-01-01), Eichel et al.
patent: 5026559 (1991-06-01), Eichel et al.
patent: 5238686 (1993-08-01), Eichel et al.
Remington's Pharmaceutical Sciences, Mack Publishing 1990, pp. 1306-1307.
Rohm Pharm-Eudragit L30 Tech. Sheet, 4 pages, Sep. 1982.

Affiliated with

Also associated with

Rating

Method for targeted and controlled release of drugs in the intes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for targeted and controlled release of drugs in the intes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for targeted and controlled release of drugs in the intes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1868660