Method for synthesizing peptides with saccharide linked enzyme p

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435180, 435181, 435183, 435188, C12P 2106, C12N 1108, C12N 1106, C12N 900, C12N 996

Patent

active

056396333

ABSTRACT:
A method is disclosed for synthesizing peptides using water soluble enzyme polymer conjugates. The method comprises catalyzing the peptide synthesis with enzyme which has been covalently bonded to a polymer through at least three linkers which linkers have three or more hydroxyl groups. The enzyme is conjugated at lysines or arginines.

REFERENCES:
patent: 3625827 (1971-12-01), Wildi et al.
patent: 3806417 (1974-04-01), Beaucamp et al.
patent: 4038140 (1977-07-01), Jaworek et al.
patent: 4081329 (1978-03-01), Jaworek et al.
patent: 4119589 (1978-10-01), Horn et al.
patent: 4182695 (1980-01-01), Horn et al.
patent: 4652524 (1987-03-01), Modrovich et al.
patent: 4673707 (1987-06-01), Tsai et al.
patent: 4711840 (1987-12-01), Nowinski et al.
patent: 4845035 (1989-07-01), Fanta
patent: 5041292 (1991-08-01), Feijen
Stryer, "Biochemistry," (1988), Freeman Co.,N.Y., pp. 302-303.
Biotechnology Letters, vol. 6, No. 12, issued 1964, K. Takahashi et al., "Polyethylene Glycol-Modified Enzymes Trap Water On Their Surface and Exert Enzymic Activity in Organic Solvents," pp. 765-770.
Die Angewandte Makromolekulare Chemie, vol. 76/77, issued 1979, U. Seitz et al., "Neu Reaktive Mikrogele als Trager fur Enzyme," pp. 319-327.
K. Takemoto et al., "Functional Monomers and Polymers, Procedures, Synthesis, Applications," published 1987 by Marcel Dekker (N.Y.), pp. 461-503.
Makromol. Chem., vol. 188, issued 1987, J. Klein, "Synthesis of Some Poly(Vinylsaccharide)s of the Amide Type and Investigation of Their Properties," pp. 1217-1232.
J. Polymer Sci., Part A-1, vol. 6, issued 1968, Y. Iwakura et al., "Preparation of Polymers Containing Sugar Residues," pp. 1625-1632.
Trends in Biochem. Sci., vol. 3, issued 1978, J.J. Marshall, "Manipulation of the Properties of Enzymes by Covalent Attachment of Carbohydrate," pp. 79-83.
Cell Surface Carb. and Biol. Recogn., issued 1978. G.R. Gray et al., "Proteins Containing Reductively Aminated Disaccharides: Chemical and Immunochemical Characterization," pp. 583-594.
Trends in Biochemical Tech., vol. 9, No. 11, issued Nov. 1991, B. Mattiasson et al., "Tailoring the Microenvironment of Enzymes in Water-Poor Systems," pp. 394-398.
Enzyme Microb. Techno.., vol. 13, issued Jul. 1991, H. Kise et al., "Immobilization of Proteases to Porous Chitosan Beads and Their Catalysis for Ester and Peptide Synthesis in Organic Solvents," pp. 584-588.
Enzyme Microb. Technol., vol. 14, issued Feb. 1992, S.A. Khan et al., "Polyethylene Glycol-Modified Substilisin Forms Microparticulate Suspensions in Organic Solvents," pp. 96-100.
Enzyme Microb. Technol., vol. 14, issued Feb. 1992, H.F. Gaertner et al., "Increased Activity and Stability of Poly(Ethylene Glycol)--Modified Trypsin," pp. 150-155.
J. Am. Chem. Soc., vol. 114, issued Jan. 1992, P. Wang et al., "New Carbohydrate-Based Materials for the Stabilization of Proteins," pp. 378-380.
Chem. Eng. News, issued 13 Jan. 1992, S. Borman, "Immobilized Enzymes Act in Organic Solvents," pp. 5-6.
Makromol. Chem., Rapid Commun., vol. 6, issued 1985, J. Klein et al., "Emulsion Polymerization of Poly (Meth-acryloylglucose)," pp. 675-678.
Makromol. Chem. Rapid Commun. vol. 7, issued 1986, A. Kobayashi et al., "Enhanced Adhesion and Survival Efficiency of Liver Cells in Culture Dishes Coated with a Lactose-Carrying Styrene Homopolymer," pp. 645-650.
O'Neil et al., Biotechnol. and Bioeng. XIII, 319-322 (1971).
Patel et al., Biopolymers 5, 577-582 (1967).
Patel & Price, Biopolymers 5, 583-584 (1967).
Robinson et al., Biochim. Biophys. Acta 242, 659-661 (1971).
Weibel & Bright, Biochem. J. 125, 801-807 (1971).
Yakunitskaya et al., Preparation of Conjugates of Subtilisin BPN' and Dextrans, 174-178 (1980).
Axen et al., Biopolymers 9, 401-413 (1970).
Barker et al., Carbohyd. Res. 20, 1-7 (1971).
Davey et al., Enzyme Microb. Technol. 11, 657-661, (1989).
Fisher & Mrozik, Macrolide Antibiotics 553-606 (1984).
Kilbanov, Chemtech 354-359 (1986).
Luthra et al., J. Chem. Soc. Perkin Trans. II. 1575-1578 (1987).
Manecke & Heise, Reactive Polymers 3, 251-260 (1985).
Mitz & Summaria, Nature 169, 576-577 (1961).
Mozhaev & Martinek, Enzyme Microb. Technol. 6, 50-59 (1984).
Russell & Klibanov. J. Biol. Chem. 263, 11624-11626 (1988).
Russell & Klibanov, Biochem. Sol. Trans., 17, 1145, (1989).
Suen & Morawetz, Makromol. Chem. 186, 255-260 (1985).
Torchilin et al., Biochimica et Biophysica Acta 522, 277-283 (1978).
Wong et al., J. Am. Chem. Soc. 945-953 112, (1990).
Wykes et al., Biochim. Biophys. Acta 250, 522-529 (1971).
Zaks & Klibanov, Proc. Natl. Acad. Sci. USA 82, 3192-3196 (1985).
Zaks & Klibanov, Science 224, 1249-1251 (1984).
Bird et al., Chemistry and Industry, 1331-1332 (1960).
Black et al., J. Chem. Soc., 4433-4439 (1963).
Black et al., Chemistry and Industry, 1624 (1962).
Haworth et al., J. Chem. Soc., 488-491 (1946).
Imoto & Kimura, Institute of Polytechnics, 210-211 (1962).
Kimura & Hirai, Institute of Polytechnics, 232-236 (1962).
Kimura & Imoto, Institute of Polytechnics, 155-160 (1961).
Klein & Blumenberg, Makromol. Chem., Rapid Communication 7, 621-625 (1986).
Nichols, Jr. et al., J. Am. Chem. Soc., 2020-2022 (1946).
Nichols, Jr. & Yanovsky, J. Am. Chem. Soc., 46-49 (1945).
Nichols, Jr. & Yanovsky, J. Am. Chem. Soc., 1625-1627 (1944).
Otey et al., Ind. Eng. Chem. Prod. Res. Dvelop. 11, 70-73 (1972).
Overberger & Takekoshi, J. of Pol. Sci. 7, 1011-1022, (1969).
Treadway & Yanovsky, J. Am. Chem. Soc., 1038-1039 (1945).
Whistler et al., J. Org. Chem., 2961-2962 (1962).
Barbas et al., J. Am. Chem. Soc. 110, 5162-5166 (1988).
Jakubke et al., Angew. Chem. Int. Ed. Engl. 24, 85-93 (1985).
Kasche, Proteolytic Enzymes, 125-143 (1989).
Kitaguchi & Klibanov, J. Am. Chem. Soc. 111, 9272-9273 (1989).
Kuhl et al., Tetrahedron Let. 21, 893-896 (1980).
Luthi & Luisi, J. Am. Chem. Soc. 106, 7285-7286 (1984).
Margolin & Klibanov, J. Am. Chem. Soc. 109, 3802-3804 (1987).
Margolin & Klibanov, J. Am. Chem. Soc. 109, 7885-7885 (1987).
Morihara & Oka, Biochem. J. 163, 531-542 (1977).
Pugh, Enzymes as Catalysts in Organic Synthesis, 217-232 (1986).
West & Wong, J. Chem. Soc., Chem. Commun. 417-418 (1986).
Gray, Preparation of Antigens, 155-160.
Lonngren and Goldstein, Preparation of Antigens, 160-162.
Smith et al., Preparation of Antigens, 169-171.
Zopf et al., Preparation of Antigens, 163-169.
Zopf et al., Preparation of Antigens, 171-175.
Cramer, Methods in Carbohydrate Chemistry 1, 242-246 (1962).
Mrozik et al., J. Med. Chem. 25, 658-663 (1982).
Richardson, Methods in Carbohydrate Chemistry 6, 218-224 (1972).
Zaborsky, Immobilized Enzymes 49-60, 149-165 (1973).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for synthesizing peptides with saccharide linked enzyme p does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for synthesizing peptides with saccharide linked enzyme p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for synthesizing peptides with saccharide linked enzyme p will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2157131

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.