Method for synthesizing esters of...

Details Method for synthesizing esters of... Method for synthesizing esters of...

2008-04-22

2008-04-22

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C544S106000, C544S170000

Reexamination Certificate

active

07361757

ABSTRACT:
A process for the synthesis of compounds of formula (I):wherein R represents a linear or branched (C1-C6)alkyl group.Application in the synthesis of perindopril and its pharmaceutically acceptable salts.

REFERENCES:
patent: 0308340 (1989-03-01), None
International Preliminary Examination Report for PCT/FR2004/002213 of Jul. 13, 2006.
W. Baker, et al., “Synthesis of the nonpeptide rennin inhibitor A-68064 and the ACE inhibitor methyl enalaprilat from (5S)-2,3,5,6-tetrahydro-5-alkyl-N-(tertbutyloxycarbonyl)-4H-1,4-oxazine-2-ones” Tetrahedron Letters, 33(12), pp. 1577-1588, 1992.
W. Baker, et al., “Synthesis and structure determination of (3S, 5S)-2,3,5,6-tetrahydro-3,5-dialkyl-N-(tert-butyloxycarbonyl)-4H-1, 4-oxazine-2-ones” Tetrahedron Letters, 33(12), pp. 1573-1576, 1992.
International Search Report for PCT/FR2004/002213,Jan. 7, 2005.
Europen Search Report for EP 03292145, Jan. 27, 2004.

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