Method for synthesizing epothilones and epothilone analogs

Details Method for synthesizing epothilones and epothilone analogs Method for synthesizing epothilones and epothilone analogs

2005-06-14

2005-06-14

Solola, Taofiq (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C549S010000, C549S267000

Reexamination Certificate

active

06906188

ABSTRACT:
A method for making epothilones and epothilone analogs is described, as are novel compounds made by the method. Exemplary novel compounds include those according to the formula:With respect the formula, G is selected from the group consisting ofR2substituents independently are selected from the group consisting of H and lower alkyl groups; Z is selected from the group consisting of the halogens and —CN; M is selected from the group consisting of O and NR3; R3is selected from the group consisting of H, lower alkyl, R4CO, R4OCO, and R4SO2; R4is selected from the group consisting of H, lower alkyl, and aryl; T is selected from the group consisting of CH2, CO, HCOH and protected derivatives thereof; W is H or OR; and X and Y independently are selected from the group consisting of O, NH, S, CO, and C. Embodiments of the method provide convenient access to analogs of the epothilones, such as those having alternate stereochemistry and those containing an ester, amide, thioester, or alkyne moieties in the macrocycle.

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