Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1996-06-27
1999-09-21
Stucker, Jeffrey
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530334, 530335, 530338, A61K 3800
Patent
active
059555777
ABSTRACT:
A method for synthesizing a water-soluble .beta.-sheet forming peptide having at least about 35% amino acids having hydrophobic side chains, the method comprising linking amino acids having charged side chains and amino acids having noncharged polar side chains with amino acids having hydrophobic side chains, wherein the amino acids having charged side chains are provided in a ratio of at least about 2:1 amino acids having positively charged side chains to amino acids having negatively charged side chains; wherein the peptide is water soluble under physiological conditions and forms .beta.-sheet structures.
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Regents of the University of Minnesota
Stucker Jeffrey
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