Method for synthesizing a specific, surface-bound polymer...

Details Method for synthesizing a specific, surface-bound polymer... Method for synthesizing a specific, surface-bound polymer...

2005-08-30

2005-08-30

Horlick, Kenneth R. (Department: 1634)

Chemistry: analytical and immunological testing

Heterocyclic carbon compound

Hetero-o

C435S006120, C435S091100, C536S023100, C536S024300, C536S024330, C536S025340

Reexamination Certificate

active

06936472

ABSTRACT:
A method for specifically and uniformly synthesizing desired polymers within molecular array elements. Droplets containing a reactive monomer are successively applied to the elements of a molecular array in order to synthesize a substrate-bound polymer. Application of an initial droplet, having a first volume, defines the position and size of a molecular array element. Subsequent droplets are applied, to add successive reactive monomers to growing nascent polymers within the molecular array element, with covering volumes so that, even when application of the subsequent droplets is misregistered, the entire surfaces of the elements of the molecular array are exposed to the subsequently applied droplets. Following application of initial droplets, the surface of the molecular array is exposed to a solution containing a very efficient capping agent in order to chemically cap any unreacted nascent growing polymers and any unreacted substrate molecules.

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patent: 5925525 (1999-07-01), Fodor et al.
patent: 6300137 (2001-10-01), Earhart et al.
patent: WO 98/16540 (1998-04-01), None
Weiler et al., Combining the preparation of oligonucleotide arrays and synthesis of high-quality primers. Anal. Biochem., 243, 218-227, 1996.

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