Method for synthesis of optically active thiolactones

Details Method for synthesis of optically active thiolactones Method for synthesis of optically active thiolactones

1974-12-13

1977-03-29

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D 4934

Patent

active

040148955

ABSTRACT:
A new method for the production of intermediates in the synthesis of an optically active biotin, which comprises reacting a dicarboxylic acid of the formula: ##SPC1##
Or its reactive derivative with an optically active primary amine, reducing the resulting trione with a metal hydride, hydrolyzing the resultant amide-alcohol and treating the thus produced lactone with a thiolactonating agent to give a thiolactone of the formula: ##SPC2##
, the said trione and amide-alcohol being respectively novel and representable by the formulae: ##SPC3##

REFERENCES:
patent: 2417326 (1947-03-01), Schnider et al.
patent: 2489232 (1949-11-01), Goldberg et al.

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