Method for synthesis of N-homocysteine thiolactonyl retinamide

Details Method for synthesis of N-homocysteine thiolactonyl retinamide Method for synthesis of N-homocysteine thiolactonyl retinamide

1999-06-30

2000-04-25

McKane, Joseph

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33332

Patent

active

06054595&

ABSTRACT:
The present invention describes a method of organic synthesis for N-homocysteine thiolactonyl retinamide, a compound that has anticancer and antiatherogenic properties.

REFERENCES:
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patent: 4383994 (1983-05-01), McCully
patent: 4618685 (1986-10-01), McCully
patent: 4925931 (1990-05-01), McCully
McCully et al., "Homocysteine and lipid metabolism in atherogenesis: effect of the homocysteine thiolactonyl derivatives, thioretinaco and thioretinamide," Atherosclerosis, 83:197-206, 1990.
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McCully and Clopath, "Homocysteine compounds which influence the growth of malignant neoplasm," Chemotherapy, 23:44-49, 1997.
McCully and Vezeridis, "Antineoplastic activity of a rhodium trichloride complex of oxalyl homocysteine thiolactone" Cancer Investigation, 5: 25-30; 1987.
McCully and Vezeridis, "Antineoplastic activity of N-maleamide homocysteine thiolactone amide encapsulated within liposomes," Proceedings of the Society of Experimental Biology and Medicine, 180: 57-61; 1985.
McCully and Vezeridis, "Chemopreventive and antineoplastic activity of N-homocysteine thiolactonyl retinamide," Carcinogenesis, 8(10):1559-1562; 1987.
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McCully et al., "Inhibition of neoplastic growth by N-homocysteine thiolactonyl retinamido cobalamin," Research Communications in Chemical Pathology and Pharmacology, 66: 117-122; 1989.
McCully et al., "Effect of the synthetic N-homocystein thiolactonyl derivatives, thioretinaco, thioretinamide and thioco on growth and lactate production by malignant cells," Research Communications in Chemical Pathology and Pharmacology, 77: 125-128; 1992.
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"Peptides: synthesis, structures, and applications," editetd by Bernd Butte. Copyright.COPYRGT. 1995 by Academic Press, Inc. San Diego, CA. p. 40-53.
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