Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamic acids – chalcogen analogs or salts thereof
Patent
1993-06-23
1994-11-22
Cintins, Marianne M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Hydroxamic acids, chalcogen analogs or salts thereof
560312, 558390, 558391, 558394, 558446, 558451, 558452, 524153, C07C25906
Patent
active
053671139
ABSTRACT:
Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which vide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.
REFERENCES:
patent: 3247197 (1966-04-01), Gaeumann et al.
patent: 4671901 (1987-06-01), Green
patent: 4764523 (1988-08-01), Heinrich
patent: 4940811 (1990-07-01), Peter
patent: 4954634 (1990-09-01), Heinrich et al.
patent: 4987253 (1991-01-01), Bergeron
patent: 4999445 (1991-03-01), White et al.
patent: 5011976 (1991-04-01), Wuts
patent: 5089644 (1992-02-01), Quay et al.
patent: 5185368 (1993-02-01), Peter
Cintins Marianne M.
MacMillan Keith
University of Florida Research Foundation Inc.
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