Method for synthesis of desferrioxamine B, analogs and homologs

Details Method for synthesis of desferrioxamine B, analogs and homologs Method for synthesis of desferrioxamine B, analogs and homologs

1991-10-30

1993-10-19

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Hydroxamate esters or chalcogen analogues thereof

562623, 558390, 558391, 558394, 558446, 558451, 558452, 564153, C07C25906

Patent

active

052547248

ABSTRACT:
Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which provide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.

REFERENCES:
patent: 3247197 (1966-04-01), Gaeumann et al.
patent: 3642805 (1972-02-01), Kisfaludy et al.
patent: 3660475 (1972-05-01), Neighbors et al.
patent: 4987253 (1991-01-01), Bergeron

Affiliated with

Also associated with

Rating

Method for synthesis of desferrioxamine B, analogs and homologs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for synthesis of desferrioxamine B, analogs and homologs , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for synthesis of desferrioxamine B, analogs and homologs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1353105