Method for synthesis of aryl difluoromethyl ethers

Details Method for synthesis of aryl difluoromethyl ethers Method for synthesis of aryl difluoromethyl ethers

1995-01-31

1998-03-24

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568 56, 548469, C07C 4976

Patent

active

057314772

ABSTRACT:
This invention relates to a method for preparing difluoromethyl ethers, thiols and amines without using chlorofluorocarbon gases. The intermediates prepared by this method can be used to make certain compounds which act as PDE IV inhibitors which are useful for treating asthma and other diseases implicated with the PDE IV isozyme.

REFERENCES:
Poludnenko et al; Zh.Org.Khim.;20(11),p. 2483, 1984.
Hendrickson et al; Third Edition; p. 544; lines 1-9, 1970.

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