Organic compounds -- part of the class 532-570 series – Organic compounds – Isonitriles
Patent
1991-11-25
1993-05-11
Brust, Joseph Paul
Organic compounds -- part of the class 532-570 series
Organic compounds
Isonitriles
534 14, C07C24900
Patent
active
052102700
ABSTRACT:
A new method for synthesizing 2-alkoxyisobutylisonitrile is provided in which isobutylene is used as the starting material. The haloalkoxylation of isobutylene in alcohol medium gives 2-alkoxyisobutylhalide which is then converted to 2-alkoxyisobutylamine. In the basic condition, the reaction of 2-alkoxyisobutylamine with chloroform produces 2-alkoxyisobutylisonitrile. The synthesis process contains three steps by which a higher yield is achieved. 2-Alkoxyisobutylisonitrile is labelled with technetium-99m by exchange labelling of stable tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex. Tetrakis(2-alkoxyisobutylisonitrile)copper(I) complex can be prepared by the exchange of acetonitrile molecules in tetrakis(acetonitrile)copper(I) complex with isonitrile ligands.
REFERENCES:
patent: 3197493 (1965-07-01), Allison
patent: 3539606 (1970-11-01), Murdoch et al.
patent: 4303786 (1981-12-01), Goldstein et al.
patent: 4452774 (1984-06-01), Jones et al.
patent: 4707544 (1987-11-01), Jones et al.
patent: 4735793 (1988-04-01), Jones et al.
patent: 4834909 (1989-05-01), Nagel
patent: 4864051 (1989-09-01), Ramalingham
patent: 4885100 (1989-12-01), Igbal et al.
patent: 4988827 (1991-01-01), Bergstein et al.
Chang-Shinn Su
Gann Ting
Shyh-Yi Chyi
Te-Wei Lee
Brust Joseph Paul
Institute of Nuclear Energy Research
LandOfFree
Method for synthesis and .sup.99m C labelling of 2-alkoxyisobuty does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for synthesis and .sup.99m C labelling of 2-alkoxyisobuty, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for synthesis and .sup.99m C labelling of 2-alkoxyisobuty will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1351663