Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1995-06-07
1998-06-02
Rollins, John W.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
514164, 514269, 514468, 514825, 514861, 514862, 514863, 514864, 514881, 514885, 514887, A61K 3578, A61K 3156
Patent
active
057595500
ABSTRACT:
An improved method for suppressing xenograft rejection in a host subject is disclosed. The method includes administering an immunosuppressant drug, where the drug or the amount of drug administered is, by itself, ineffective to suppress xenograft rejection. Effective xenograft suppression is achieved by also administering an ethanolic extract of Triterygium wilfordii or a purified triptolide component thereof.
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Briggs, J.D., "A critical review of immunosuppressive therapy", Immunol. Let. 29:89-94,1, 1991.
Chen, K., et al., "Anti-AIDS Agents, 4. Tripterifordin, a Novel Anti-HIV Principle From Tripterygium wilfordii: Isolation and Structural Elucidation", J. Nat. Prod. 55(1):88-92, 1992.
Huying, S., et al., "Effects of Tripterygium wilfordii on the Menstruation of 50 Patients Suffering From Rheumatoid Arthritis--With a Summary of its Trerapeutic Effects in 12 Cases of Menorrhagia", JTrad. Chin. Med. 4(3):234-240, 1984.
Liao, C.X. et al., Antirejection Thereapy with Tripterygium wolfordii and Low-Dose Cyclosporin A in Small Bowel Transplantation in Pigs, Bull. Jinling Hosp. 6:265 (1992).
Wang Jian
Wiedmann Tien Wen Tao
Gorthey LeeAnn
Pharmagenesis, Inc.
Powers Vincent M.
Rollins John W.
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