Method for suppressing immune response associated with psoriasis

Details Method for suppressing immune response associated with psoriasis Method for suppressing immune response associated with psoriasis

1993-08-19

1996-02-06

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Inorganic active ingredient containing

Heavy metal or compound thereof

424719, 514885, A01N 5916, A61K 3324

Patent

active

054894417

ABSTRACT:
This invention relates to the use of Ruthenium Red as an immunosuppressive agent to prevent or significantly reduce graft rejection in organ and bone marrow transplantation. Ruthenium Red can also be used as an immunosuppressant drug for T lymphocyte mediated autoimmune diseases, such as diabetes. Furthermore, Ruthenium Red may be useful in alleviating psoriasis and contact dermatitis.

REFERENCES:
patent: 5308623 (1994-05-01), Fues et al.
Kapus et al., "Ruthenium Red Inhibits Mitochondrial Na+ and K+ Uniports Induced by Magnesium Removal", J. of Biological Chemistry, 265(30): 18063-18066 (1990).
Missiaen et al., "Ruthenium Red and Compound 48/80 Inhibit the Smooth-Muscle Plasma-Membrane . . . ", Biochimica et Biophysica Acta, 1023: 449-454 (1990).
Tsuruo et al., "Growth Inhibition of Lewis Lung Carcinoma by an Inorganic Dye, Ruthenium Red", Gann, 71:151-154 (1980).
Dornand et al., "PCP and Analogs Prevent the Proliferative Response of T Lymphocytes . . . ", Biochemical Pharmacology, 36(22): 3929-3936 (1987).
Broekemeier et al., "Cyclosporin A Is a Potent Inhibitor of the Inner Membrane Permeability Transition in Liver Mitochondria", J. of Biological Chemistry, 264(14):7826-7830 (1989).

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