Method for suppressing coloring of human serum albumin

Details Method for suppressing coloring of human serum albumin Method for suppressing coloring of human serum albumin

1993-03-16

1994-11-29

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435171, 530364, C12P 102, C12P 2102

Patent

active

053690206

ABSTRACT:
A method for suppressing coloring of human serum albumin expressed by genetic engineering, which comprises culture and/or purification in the presence of an amine compound selected from the group consisting of alkylamines, diamines, guanidines, benzamidines, basic amino acids, and aminophenylacetic acids. According to the present invention, coloring of HSA expressed by genetic engineering can be suppressed to from one-half to one-tenth of that without treatment for coloring suppression. In addition, HSA can be recovered in high yields, and the treatment of the invention does not affect the inherent properties of HSA.

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Quirk, A. V. et al.; Biol. Abstracts 88:36945 (1989).
Sreekrishna et al.; Biochemistry 28:4117-4125 (1989).
Kemp, D. S. et al.; Organic Chemistry, Worth Publishers Inc., NY (1980) pp. 412-414.

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