Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1996-10-31
1999-05-25
Saucier, Sandra E.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
424 9375, A61K 3518, A61K 3514
Patent
active
059069155
ABSTRACT:
The present invention provides an improved aqueous solution for suspending and storing red blood cells. The solution includes sodium citrate, a combination of sodium biphosphate and sodium phosphate dibasic, adenine, and mannitol. The solution is formulated at a low osmolarity and has a physiological pH of approximately 7.4. The solution simultaneously maintains stored red cells ATP and 2,3-BPG. Also disclosed is a method for storing red blood cells comprising adding an anticoagulant with a reduced citrate concentration compared to a CPD solution comprising 26.3 g/l, sodium citrate and 3.28 g/l citric acid hydrous to whole blood, separating the red cells and adding a storage solution comprising sodium citrate, sodium diphosphate, sodium phosphate dibasic, adenine and mannitol.
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Debrauwere Jack
Hogman Claes F.
Mathias Jean Marie
Payrat Jean-Marc
Barrett Robert M.
Baxter International Inc.
Price Bradford R. L.
Saucier Sandra E.
Serewicz Denise M.
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