Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2007-10-16
2007-10-16
Bunner, Bridget (Department: 1647)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C424S198100, C514S012200, C530S350000, C530S399000
Reexamination Certificate
active
10623567
ABSTRACT:
The present invention relates to a method for stimulating wound healing, and more particularly to a method for stimulating wound healing in a subject in need thereof, comprising administering to a wound of the subject an effective amount for stimulating wound healing of a composition, wherein the composition comprises p43 having an amino acid sequence set forth in SEQ ID NO: 1 or functional equivalents thereof. The composition used in the method of the present invention can be efficiently utilized for the wound healing, since p43, an effective ingredient of the composition, has an excellent effect on the wound healing by its action including the induction of macrophage/monocyte and endothelial cell, re-epithelization, proliferation of fibroblasts or angiogenesis.
REFERENCES:
patent: 6875749 (2005-04-01), Schwarz et al.
patent: 6916648 (2005-07-01), Goddard et al.
patent: WO 200195927 (2001-12-01), None
Gallucci, et al FASEB J. 14:2525-2531, 2000 ‘Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice’.
Park et al. Dose-dependent biphasic activity of tRNA synthetas-associating factor, p43, in angiogenesis. J Biol Chem 277(47): 45243-45248, 2002.
Park et al. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am J Pathol 166(2): 387-398, 2005).
Steed, D.L., “Modifying the Wound Healing Response With Exogenous Growth Factors,” Clinics in Plastic Surgery, Jul. 1998, pp. 397-405, vol. 25, No. 3.
Bennett, N.T. et al., “Growth Factors and Wound Healing: Biochemical Properties of Growth Factors and Their Receptors,” Am J. Surgery, Jun. 1993, pp. 728-737, vol. 165.
Knighton, D.R. et al., “Regulation of Cutaneous Wound Healing by Growth Factors and the Microenvironment,” Invest. Radiol., Jun. 1991, pp. 604-611, vol. 26.
Berger, A.C. et al., “Endothelial Monocyte-Activating Polypeptide II, a Tumor-Derived Cytokine That Plays an Important Role in Inflammation, Apoptosis, and Angiogenesis,” J. Immunother., 2000, pp. 519-527, vol. 23, No. 5.
Ko, Y.-G. et al., “A Cofactor of tRNA Synthetase, p43, is Secreted to Up-regulate Proinflammatory Genes,” J. Biol. Chem., Jun. 22, 2001, pp. 23028-23033, vol. 276, No. 25.
Chang, S.Y. et al., “Interaction of the C-terminal Domain of p43 and the α Subunit of ATP Synthase,” J. Biol. Chem., Mar. 8, 2002, pp. 8388-8394, vol. 277, No. 10.
Park, H. et al., “Monocyte cell adhesion induced by a human aminoacyl-tRNA synthetase-associated factor, p43: identification of the related adhesion molecules and signal pathways,” J. Leukocyte Biol., Feb. 2002, pp. 223-230, vol. 71.
Cecconi, F. et al., “Gene trap: a way to identify novel genes and unravel their biological function,” FEBS Letts., 2000, pp. 63-71, vol. 480.
Zambrowicz, B.P. et al., “Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells,” Nature, Apr. 9, 1998, pp. 608-611, vol. 392.
Southern, E.M., “Detection of Specific Sequences Among DNA Fragments Separated by Gel Electrophoresis,” J. Mol. Biol., 1975, pp. 503-517, vol. 98.
Ziak, M. et al., “Two Isoforms of Trimming Glucosidase II Exist in Mammalian Tissues and Cell Lines but Not in Yeast and Insect Cells,” Biochem. And Biophys. Res. Comm., 2001, pp. 363-367, vol. 280, No. 1.
Park, S.G. et al., “Precursor of Pro-apoptotic Cytokine Modulates Aminoacylation Activity of tRNA Synthetase,” J. Biol. Chem., Jun. 11, 1999, pp. 16673-16676, vol. 274, No. 24.
Werner, S. et al., “The Function of KGF in Morphogenesis of Epithelium and Reepithelialization of Wounds,” Science, Nov. 4, 1994, pp. 819-822, vol. 266.
Lund, L.R. et al., “Functional overlap between two classes of matrix-degrading proteases in wound healing,” The EMBO Journal, 1999, pp. 4645-4656, vol. 18, No. 17.
Ben-Izhak, O. et al., “Ki67 antigen and PCNA proliferation markers predict survival in anorectal malignant melanoma,” Histopathology, 2002, pp. 519-525, vol. 41.
aTyr Pharma, Inc.
Bell Boyd & Lloyd LLP
Bunner Bridget
LandOfFree
Method for stimulating wound healing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for stimulating wound healing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for stimulating wound healing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3877917